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Pleomorphic adenoma of salivary gland

MedGen UID:
275400
Concept ID:
C1519176
Neoplastic Process
Synonyms: Pleomorphic adenoma; Salivary gland adenoma, pleomorphic
SNOMED CT: Pleomorphic adenoma of salivary gland (447888006)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Gene (location): PLAG1 (8q12.1)
 
Monarch Initiative: MONDO:0008401
OMIM®: 181030
Orphanet: ORPHA454821

Definition

A rare tumor of salivary glands characterized by a benign, well-circumscribed, slow-growing, painless mass most commonly occurring in the parotid gland (but also the palate, submandibular gland, or nasal septal mucosa), histopathologically composed of epithelial and myoepithelial / stromal components. Possible signs and symptoms depend on the location of the tumor and include facial nerve weakness, mild dysphagia, or unilateral nasal obstruction. Recurrence rates are low, although tumor rupture and spillage have been reported. Malignant transformation may occur in a small percentage of cases. [from ORDO]

Clinical features

From HPO
Salivary gland neoplasm
MedGen UID:
20641
Concept ID:
C0036095
Neoplastic Process
A tumor (abnormal growth of tissue) of a salivary gland.

Professional guidelines

PubMed

Gupta RK, Naran S, Dowle C, Simpson JS
Cytopathology 1992;3(5):303-9. doi: 10.1111/j.1365-2303.1992.tb00052.x. PMID: 1283826

Recent clinical studies

Etiology

Hamada T, Matsukita S, Goto M, Kitajima S, Batra SK, Irimura T, Sueyoshi K, Sugihara K, Yonezawa S
J Clin Pathol 2004 Aug;57(8):813-21. doi: 10.1136/jcp.2003.014043. PMID: 15280401Free PMC Article
Marioni G, Marino F, Stramare R, Marchese-Ragona R, Staffieri A
Head Neck 2003 Dec;25(12):1071-6. doi: 10.1002/hed.10319. PMID: 14648866

Diagnosis

Haskell HD, Butt KM, Woo SB
Am J Surg Pathol 2005 Oct;29(10):1389-93. doi: 10.1097/01.pas.0000168509.47243.4b. PMID: 16160483
Das DK, Anim JT
Cytopathology 2005 Apr;16(2):65-70. doi: 10.1111/j.1365-2303.2004.00208.x. PMID: 15787647
Asai S, Tang X, Ohta Y, Tsutsumi Y
Pathol Int 1995 Sep;45(9):677-83. doi: 10.1111/j.1440-1827.1995.tb03521.x. PMID: 8548041
Pitman MB, Thor AD, Goodman ML, Rosenberg AE
Diagn Cytopathol 1992;8(4):384-7. doi: 10.1002/dc.2840080417. PMID: 1322265
Takahashi H, Tsuda N, Tezuka F, Okabe H
Tohoku J Exp Med 1986 Jul;149(3):329-40. doi: 10.1620/tjem.149.329. PMID: 3020738

Therapy

Alaizari NA, Tarakji B, Al-Maweri SA, Al-Shamiri HM, Darwish S, Baba F
Arch Oral Biol 2015 Sep;60(9):1437-41. Epub 2015 Jun 23 doi: 10.1016/j.archoralbio.2015.06.019. PMID: 26163983

Prognosis

Hamada T, Matsukita S, Goto M, Kitajima S, Batra SK, Irimura T, Sueyoshi K, Sugihara K, Yonezawa S
J Clin Pathol 2004 Aug;57(8):813-21. doi: 10.1136/jcp.2003.014043. PMID: 15280401Free PMC Article

Clinical prediction guides

Silva LP, da Silva LAB, Sedassari BT, de Sousa SCOM, Dos Santos Pereira J, de Souza LB, da Costa Miguel MC
Eur Arch Otorhinolaryngol 2018 Jun;275(6):1595-1600. Epub 2018 Mar 29 doi: 10.1007/s00405-018-4960-1. PMID: 29594385
Nakajima Y, Kishimoto T, Nagai Y, Yamada M, Iida Y, Okamoto Y, Ishida Y, Nakatani Y, Ichinose M
Pathology 2009;41(7):634-9. doi: 10.3109/00313020903071595. PMID: 19672785
Hamada T, Matsukita S, Goto M, Kitajima S, Batra SK, Irimura T, Sueyoshi K, Sugihara K, Yonezawa S
J Clin Pathol 2004 Aug;57(8):813-21. doi: 10.1136/jcp.2003.014043. PMID: 15280401Free PMC Article
Lianjia Y, Yan J, Hitoshi N, Shinichiro S, Akihide K, Masahiko M
Virchows Arch A Pathol Anat Histopathol 1993;422(6):439-43. doi: 10.1007/BF01606451. PMID: 8333147
Takahashi H, Tsuda N, Tezuka F, Okabe H
Tohoku J Exp Med 1986 Jul;149(3):329-40. doi: 10.1620/tjem.149.329. PMID: 3020738

Recent systematic reviews

Alaizari NA, Tarakji B, Al-Maweri SA, Al-Shamiri HM, Darwish S, Baba F
Arch Oral Biol 2015 Sep;60(9):1437-41. Epub 2015 Jun 23 doi: 10.1016/j.archoralbio.2015.06.019. PMID: 26163983

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